Water in Biological and Chemical Processes: From Structure and Dynamics to FunctionBuilding up from microscopic basics to observed complex functions, this insightful monograph explains and describes how the unique molecular properties of water give rise to its structural and dynamical behaviour which in turn translates into its role in biological and chemical processes. The discussion of the biological functions of water details not only the stabilising effect of water in proteins and DNA, but also the direct role that water molecules themselves play in biochemical processes, such as enzyme kinetics, protein synthesis and drug-DNA interaction. The overview of the behaviour of water in chemical systems discusses hydrophilic, hydrophobic and amphiphilic effects, as well as the interactions of water with micelles, reverse micelles, microemulsions and carbon nanotubes. Supported by extensive experimental and computer simulation data, highlighting many of the recent advances in the study of water in complex systems, this is an ideal resource for anyone studying water at the molecular level. |
Contents
3 | |
Anomalies of water | 13 |
molecular motions and hydrogenbondbreaking | 27 |
Inherent structures of liquid water | 61 |
The pH of water | 71 |
Biological water | 81 |
water in biological functions | 97 |
Hydration of proteins | 117 |
The hydrophilic effect 201 201 | 201 |
The hydrophobic effect | 215 |
the diverse but intimate world of aqueous | 243 |
91 | 259 |
Water in and around micelles reverse micelles and microemulsions | 261 |
nature abhors a vacuum | 277 |
The entropy of water | 287 |
The freezing of water into ice | 305 |
A Orientation of water molecules in the hydration layer | 132 |
Water in and around DNA and RNA | 151 |
the role of water as a facilitator | 167 |
its role as a lubricant | 177 |
The role of water in biochemical selection and protein synthesis | 187 |
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Common terms and phrases
5-coordinated Adapted with permission American Chemical Society amino acid amphiphilic anomalies aqueous Bagchi binary mixtures biological bond bulk water carbon nanotubes chapter Chem coefficient component computer simulations concentration constant Copyright correlation function decay decreases density dielectric diffusion discussed DMSO dynamics of water electrolyte energy enthalpy entropy entropy of water enzyme experimental Figure adapted fluctuations formation free-energy freezing HB network hydration hydrogen hydrogen-bonded hydrophilic hydrophobic effect hydrophobic surface increase interaction interface ions kinetic large number lipid bilayer liquid water mechanism micelles microscopic minor groove mole molecular dynamics motion nanotubes non-polar solute observed obtained pair phase Phys polar potential properties reaction region residues reverse micelles role of water rotational shown in Figure shows simulation studies solvation solvation dynamics solvent stability supercooled supercritical supercritical fluids theory thermodynamic timescale transition translational tRNA understanding vibrational viscosity water dynamics water molecules Widom line