Water in Biological and Chemical Processes: From Structure and Dynamics to Function

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Cambridge University Press, Nov 14, 2013 - Science - 376 pages
Building up from microscopic basics to observed complex functions, this insightful monograph explains and describes how the unique molecular properties of water give rise to its structural and dynamical behaviour which in turn translates into its role in biological and chemical processes. The discussion of the biological functions of water details not only the stabilising effect of water in proteins and DNA, but also the direct role that water molecules themselves play in biochemical processes, such as enzyme kinetics, protein synthesis and drug-DNA interaction. The overview of the behaviour of water in chemical systems discusses hydrophilic, hydrophobic and amphiphilic effects, as well as the interactions of water with micelles, reverse micelles, microemulsions and carbon nanotubes. Supported by extensive experimental and computer simulation data, highlighting many of the recent advances in the study of water in complex systems, this is an ideal resource for anyone studying water at the molecular level.
 

Contents

Uniqueness of water
3
Anomalies of water
13
molecular motions and hydrogenbondbreaking
27
Inherent structures of liquid water
61
The pH of water
71
Biological water
81
water in biological functions
97
Hydration of proteins
117
The hydrophilic effect 201 201
201
The hydrophobic effect
215
the diverse but intimate world of aqueous
243
91
259
Water in and around micelles reverse micelles and microemulsions
261
nature abhors a vacuum
277
The entropy of water
287
The freezing of water into ice
305

A Orientation of water molecules in the hydration layer
132
Water in and around DNA and RNA
151
the role of water as a facilitator
167
its role as a lubricant
177
The role of water in biochemical selection and protein synthesis
187
Supercritical water
317
Approaches to understand water anomalies
323
Epilog
345
8
352
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About the author (2013)

Biman Bagchi is a Professor at the Indian Institute of Science, Bangalore. He is a Fellow of the Indian National Science Academy, the Indian Academy of Sciences, The National Academy of Sciences, India, and TWAS, the academy of sciences for the developing world, Italy.

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