The Double Helix: A Personal Account of the Discovery of the Structure of DNAThe classic personal account of Watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind. By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries. With humility unspoiled by false modesty, Watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work. |
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Page 186
... guanine ) and the pyri- midines ( thymine and cytosine ) have different shapes . The resulting backbone would have to show minor in- and - out buckles depending upon whether pairs of purines or pyrimidines were in the center . Despite ...
... guanine ) and the pyri- midines ( thymine and cytosine ) have different shapes . The resulting backbone would have to show minor in- and - out buckles depending upon whether pairs of purines or pyrimidines were in the center . Despite ...
Page 191
... guanine The contrasting tautomeric forms of guanine and thymine which might occur in DNA . The hydrogen atoms that can undergo the changes in position ( a tautomeric shift ) are shaded . H Jerry , however , did not give a foolproof reason.
... guanine The contrasting tautomeric forms of guanine and thymine which might occur in DNA . The hydrogen atoms that can undergo the changes in position ( a tautomeric shift ) are shaded . H Jerry , however , did not give a foolproof reason.
Page 196
... guanine could pair only with cytosine . Chargaff's rules then suddenly stood out as a consequence of a double - helical structure for DNA . Even more exciting , this type of double helix sug- gested a replication scheme much more ...
... guanine could pair only with cytosine . Chargaff's rules then suddenly stood out as a consequence of a double - helical structure for DNA . Even more exciting , this type of double helix sug- gested a replication scheme much more ...
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Common terms and phrases
a-helix adenine answer argument arranged arrival atoms bacterial base pairs biochemistry biological Cal Tech Cambridge Cavendish chains Chargaff's Chargaff's rules chemical chemistry chemists College conversation Copenhagen crystallographic crystals cytosine Delbrück dinner DNA molecule DNA structure double helix Elizabeth existed experimental experiments fact fellowship Francis Crick genes genetic geneticists girls Griffith guanine Herman hope Hugh Huxley hydrogen bonds idea immediately important ions John Kendrew keto King's knew large number letter Linus Pauling London look lunch Luria manuscript Maurice Wilkins Maurice's Max and John Max Perutz ment model building molecular Moreover morning never Nonetheless nucleic acids nucleotides Odile Pauling's Perutz Peter phage phosphate groups polynucleotide Pop's possibility problem protein purine purine and pyrimidine pyrimidine quickly realized reason Rosalind Franklin Rosy Rosy's scientific solve soon sugar sugar-phosphate backbone talk tautomeric forms tell thought thymine tion told walked wanted Watson week X-ray photograph X-ray pictures