Acetylcholine: An Approach to the Molecular Mechanism of ActionAcetylcholine: An Approach to the Molecular Mechanism of Action is an in-depth study of neurotransmitter system, with much focus on acetylcholine and its action and the cholinergic synapse. The book, divided into seven chapters, covers the following topics: the function of the cholinergic synapse; the movement of ions across membranes; the excitatory postsynaptic potential; the nature of cholinoreceptors and cholinesterases; the structure of its active centers; and the pattern of arrangement of the receptors of the cholinoreceptive membrane. The book also covers the quantitative evaluation of the action of neurotransmitters; the reactive capacity of the acetylcholine molecule and its effects on nerve endings and nerve fibers; and the release of mediators and hormones. The text is recommended for those who specialize in the fields of biology, medicine, biochemistry, and pharmacology, especially those wish to study about the neurotransmitter system, cholinoreceptors, the cholinergic synapse, the acetylcholine, and its action. |
Contents
CHAPTER 2 The Nature of Cholinoreceptors and Cholinesterases and Methods of Study of their Chemical Structure
| 33 |
CHAPTER 3 The Quantitative Evaluation of the Action of Substances that Stimulate and Block the Cholinoreceptor
| 45 |
CHAPTER 4 The Reactive Capacity of the Acetylcholine Molecule and the Structure of the Active Centres of ChoHnoreceptors and Cholinesterases
| 73 |
CHAPTER 5 Patterns of Arrangement of Individual Receptors on the Cholinoreceptive Membrane
| 125 |
CHAPTER 6 Changes in the Pattern of Arrangement of Cholinoreceptors in the Process of Evolution | 161 |
CHAPTER 7 NonSynaptic Cholinoreceptors | 187 |
References | 203 |
Author Index | 229 |
| 237 | |
Other Titles in the Division Modern Trends in Physiological Sciences | 243 |
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Common terms and phrases
acetylcholine ACh molecule acid action of ACh active centres agonist alkylating anionic anionic centre anionic group anionic portion antagonist anticholinesterase arecoline atropine Barlow blocking activity C16 structure carbachol carbolonium carbonyl cationic head chain choline cholinergic cholinesterase cholinolytic action cholinomimetic activity cholinoreceptors complex concentration curare Danilov decamethonium denervation depolarization desensitization dicholine dose effect elicit endplate enzyme equation equilibrium ester ester group esteratic esterophilic portions ether oxygen evoked ganglia ganglion hydrophobic hydrophobic portions hypothesis increase inhibition inhibitors injection ions Kabachnik Katz Khromov-Borisov Koelle M-ChR Magazanik maximal mediator methyl groups Michelson Miledi muscarine muscle fibre muscle relaxants N-ChR nerve endings neurones nicotine nitrogen nitrogen atoms obtained Paton pattern of arrangement permeability potential presence presynaptic protein quaternary nitrogen radicles receptors rectus abdominis muscle reduced Renshaw cells response sartorius muscle sebacoyldicholine sensitivity sixteen atoms skeletal muscle stimulation suberyldicholine substance suxamethonium synapses Table tertiary Thesleff transmission tubocurarine Turpaev uM/kg Vulfius Zeimal